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KMID : 0363320020230020191
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Journal of Korean Oriental Internal Medicine
2002 Volume.23 No. 2 p.191 ~ p.201
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Effects of Yukmijihwang-tang to Recover the Brain Damage of Mice
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Kim Yong-Jin
Kim Bang-Oul
Kim Kyung-Sun
Jeon Hong-Youl
Kang Hwa-Jeong
Kim Jeong-Sang
Hong Seok
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Abstract
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Objectives : This study was designed to investigate the effects of Yukmijihwang-tang on contusion of the mice induced with medicine.
Methods : I observed the effects of light and electron microscopes. and examined hematological changes and VEGF-immunohistochemistry.
Results : Hematology: Leukocytes were increased significantly in a control group of mice compared with the experimental group.
Light microscope : A few neurons were condensed in the 7-day experimental group, but condensed remarkedly in the 3-day control group. Most glial cells were observed in the 3-day experimental group. Edema and dilatation of vessels occurred significantly in the 3-day control group, and these results occurred weakly in the 7-day experimental group.
VEGF-immunohistochemistry : VEGF-immunohistochemical reactivity for the glial cells was the highest in the 3-day experimental group, and immunoreactivity for the vessels and neurons highly increased in the 7-day experimental group.
Electron microscope : In the 3-day control group, protoplasmic astrocytes concerned with angiogenesis contained weakly developed rough endoplasmic reticulum. and a few of glial filaments were observed. In the 7-day experimental group, the bundles of glial filaments were found in the cytoplasmic process of astrocytes.
Conclusion : medication using Yukmijihwang-tang of mice contused by medical stress is highly effective in inflamatory response, curing cell damage and angiogenesis.
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KEYWORD
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Yukmijihwang-tang, VEGF-immunohistochemistry, angiogenesis
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